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The combination is associated with hepatic steatosis, increased VLDL production, endothelial dysfunction, and pro-inflammatory adipokine signaling

However, pairing GLP-1 supplementation with the right lifestyle changes may support better appetite control and consistency

Krishnan S, Adams SH, Witbracht MG, Woodhouse LR, Piccolo BD, Thomas AP, et al

employed two NAFLD animal models (MCD diet and HFD mice), which underwent partial hepatectomy after treatment with G49, a dual GLP-1/GCG receptor agonist